Safety Info. What you should know about LATISSE®
If you're considering LATISSE® (bimatoprost ophthalmic solution) 0.03%, it's important to gather information. You may have questions about how the treatment works, how soon you'll see results, and the safety of the product. This site was intended to give you a basic understanding of the product, but you should ask your doctor to see if LATISSE® is right for you.
Possible side effects.

The most common side effects after using LATISSE® are an itching sensation in the eyes and/or eye redness, which were reported in approximately 4% of clinical trial patients. LATISSE® solution may cause other less common side effects which typically occur close to where LATISSE® is applied. These include skin darkening, eye irritation, dryness of the eyes and redness of the eyelids.

Special warnings.

LATISSE® solution is intended for use on the skin of the upper eyelid margins at the base of the eyelashes. Refer to the illustration below. DO NOT APPLY to the lower lid. If you are using LUMIGAN® ophthalmic solution or other products for elevated intraocular pressure (IOP), or if you have a history of abnormal IOP, you should only use LATISSE® under the close supervision of your physician. If you develop or experience any eye problems or have eye surgery, consult your doctor immediately about continued use of LATISSE®.

LATISSE® application

LATISSE® solution use may cause darkening of the eyelid skin which may be reversible. Although not seen in the clinical studies, may also cause increased brown iris pigmentation of the colored part of the eye which is likely to be permanent. Increased iris pigmentation has occurred when the same formulation of bimatoprost ophthalmic solution was instilled directly into the eye.

It is possible for hair growth to occur in other areas of your skin that LATISSE® frequently touches. Any excess solution outside the upper eyelid margin should be blotted with a tissue or other absorbent material to reduce the chance of this happening. It is possible for a difference in eyelash length, thickness, fullness, pigmentation (darkness), number of eyelash hairs and/or direction of eyelash growth to occur between eyes (e.g., results may vary for each eye). These differences, should they occur, will usually go away if you stop using LATISSE®.

Some important application tips.

When applying LATISSE® solution, it's important to follow the complete directions. Here are a few simple things to keep in mind:

  • Do not apply in the eye or to the lower eyelid.
  • Only use the sterile applicators supplied with LATISSE® to apply the product.
  • Don't allow the tip of the bottle, or applicator, to touch fingers or any other unintended surface, as contamination by common bacteria is known to cause infections.
  • Remove contact lenses prior to applying LATISSE®. Contact lenses may be reinserted 15 minutes afterward.
  • Remember, if you stop using LATISSE®, lashes will gradually return to their previous appearance.

To learn more, ask your doctor and see the Product Information.

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LATISSE® Indication
LATISSE® Important Safety Information
If you are using, or have used, prescription products for any eye pressure problems, only use LATISSE® under close doctor care. Although not seen in LATISSE® clinical studies, may cause increased brown pigmentation of the colored part of the eye which is likely permanent. Eyelid skin darkening may occur which may be reversible. Only apply at the base of the upper eyelashes. DO NOT APPLY to the lower eyelid. Hair growth may occur in other skin areas that LATISSE® solution frequently touches. If you develop or experience any eye problems or have eye surgery, consult your doctor immediately about continued use of LATISSE®. The most common side effects after using LATISSE® solution are itchy eyes and/or eye redness. If discontinued, lashes will gradually return to their previous appearance.
BOTOX® Cosmetic Important Information
Indication
IMPORTANT SAFETY INFORMATION

BOTOX® Cosmetic may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have any of these problems any time (hours to weeks) after injection of BOTOX® Cosmetic:

  • Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months.

  • Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms including: loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice (dysphonia), trouble saying words clearly (dysarthria), loss of bladder control, trouble breathing, trouble swallowing.

There has not been a confirmed serious case of spread of toxin effect when BOTOX® Cosmetic has been used at the recommended dose to treat frown lines.

The dose of BOTOX® Cosmetic is not the same as, or comparable to, another botulinum toxin product.

Serious and/or immediate allergic reactions have been reported. These reactions include itchy rash, swelling, and shortness of breath. Tell your doctor or get medical help right away if you experience any such symptoms, further injection of BOTOX® Cosmetic should be discontinued.

Do not take BOTOX® Cosmetic if you: are allergic to any of the ingredients in BOTOX® Cosmetic (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as Myobloc® or Dysport®; have a skin infection at the planned injection site.

Tell your doctor about all your muscle or nerve conditions such as amyotrophic lateral sclerosis [ALS or Lou Gehrig's disease], myasthenia gravis or Lambert-Eaton syndrome as you may be at increased risk of serious side effects including severe dysphagia (difficulty swallowing) and respiratory compromise (difficulty breathing) from typical doses of BOTOX® Cosmetic.

Tell your doctor about all your medical conditions, including if you have: plans to have surgery; had surgery on your face; weakness of forehead muscles, such as trouble raising your eyebrows; drooping eyelids; any other abnormal facial change; are pregnant or plan to become pregnant (It is not known if BOTOX® Cosmetic can harm your unborn baby); are breast-feeding or plan to breastfeed (It is not known if BOTOX® Cosmetic passes into breast milk).

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins and herbal products.

BOTOX® Cosmetic may cause loss of strength or general muscle weakness, or vision problems. If this happens, do not drive a car, operate machinery, or do other dangerous activities.

Other side effects of BOTOX® Cosmetic include: dry mouth, discomfort or pain at the injection site, tiredness, headache, neck pain, and eye problems: double vision, blurred vision, decreased eyesight, drooping eyelids, swelling of your eyelids, and dry eyes.
For more information refer to the Medication Guide or talk with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see BOTOX® Cosmetic full Product Information, including Medication Guide.

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